Expression of glucose transporter isoform GLUT-2 and glucokinase genes in human brain
نویسندگان
چکیده
منابع مشابه
Regulation of glucokinase and GLUT-2 glucose-transporter gene expression in pancreatic B-cells.
Glucokinase (EC 2.7.1.2) is the signal-recognition enzyme in pancreatic B-cells for initiation of glucose-induced insulin secretion. We show here that both the glucokinase and glucose-transporter GLUT-2 genes are regulated physiologically. Fasting decreased B-cell glucokinase and glucose-transporter GLUT-2 mRNA in pancreatic B-cells as well as in liver, whereas refeeding induced expression of b...
متن کاملExpression and function of GLUT-1 and GLUT-2 glucose transporter isoforms in cells of cultured rat pancreatic islets.
We have previously investigated glucose induction of glucokinase, glucose usage and insulin release in isolated cultured rat pancreatic islets (Liang, Y., Najafit, H., Smith, R. M., Zimmerman, E. C., Magnuson, M. A., Tal, M., and Mastchinsky, F. M. (1992) Diabetes (1992) 41, 792-806). Here we studied the expression and function of GLUT-1 and GLUT-2 glucose transporter isoforms, using the same s...
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Complementary DNAs encoding the mouse GLUT3/brain facilitative glucose transporter have been isolated and sequenced. The predicted amino acid sequence indicates that mouse GLUT3 is composed of 493 amino acids and has 83 and 89% identity and similarity, respectively, to the sequence of human GLUT3. In contrast to human GLUT3 mRNA, which can be readily detected by RNA blotting in all human tissue...
متن کاملGlucokinase and glucose transporter expression in liver and islets: implications for control of glucose homoeostasis.
The liver/islet high-K, facilitated glucose transporter (GLUT-2) and the glucose phosphorylating enzyme, glucokinase, are key regulators of the rate of glucose metabolism in liver and islets, the two ‘glucose-sensing’ tissues in mammals. Increases in circulating glucose stimulate insulin secretion from the ,%cells of the islets of Langerhans and convert the liver from an organ o f net glucose o...
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The adipocytokine resistin impairs glucose tolerance and insulin sensitivity. Here, we examine the effect of resistin on glucose uptake in human trophoblast cells and we demonstrate that transplacental glucose transport is mediated by glucose transporter (GLUT)-1. Furthermore, we evaluate the type of signal transduction induced by resistin in GLUT-1 regulation. BeWo choriocarcinoma cells and pr...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2004
ISSN: 0022-3042
DOI: 10.1046/j.1471-4159.2003.02269.x